methyl 3-[(2S,3R)-2-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl]propanoate
Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate
CAS: 204589-80-0
Molecular Formula: C26H24FNO4
methyl 3-[(2S,3R)-2-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl]propanoate - Names and Identifiers
methyl 3-[(2S,3R)-2-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl]propanoate - Physico-chemical Properties
| Molecular Formula | C26H24FNO4 |
| Molar Mass | 433.47 |
| Density | 1.238 |
| Boling Point | 628.309°C at 760 mmHg |
| Flash Point | 333.789°C |
| Vapor Presure | 0mmHg at 25°C |
| Storage Condition | 2-8°C |
| Refractive Index | 1.589 |
methyl 3-[(2S,3R)-2-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl]propanoate - Introduction
Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate, also known as Fmoc-L-phosphoserine ester, is an organic compound. The following is an introduction to its nature, use, preparation and safety information:
Nature:
-Appearance: White or off-white solid
-Molecular formula: C31H29FN3O6P
-Molecular weight: 605.56g/mol
-Melting point: about 130-145 ° C
-Solubility: Slightly soluble in water, soluble in some organic solvents
Use:
- Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate is mainly used for peptide synthesis in the fields of biochemistry and organic synthesis, especially the study of peptide modification.
-It can be used as an intermediate in the design and synthesis of anti-cancer drugs, and has anti-tumor activity.
-It can also be used for protecting groups in polypeptide synthesis and solid phase synthesis.
Method:
The preparation of Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate usually adopts the method of organic synthesis, it can be synthesized in the laboratory by the following steps:
1. Preparation of (4-fluorophenyl) propionitrile
2. (4-fluorophenyl) propionitrile reacts with P-benzophenol to generate (4-(benzyloxy) phenyl) propionitrile
3. Reaction of (4-(benzyloxy) phenyl) propionitrile with (2R,3S)-1-benzylamino-2-oxo-3-azetidine yields (2R,3S)-1-(4-(Benzyloxy) phenyl)-2-oxo-4-cyano-3-azetidine
4. Reaction of (2R,3S)-1-(4-(benzyloxy) phenyl)-2-oxo-4-cyano-3-azetidine with methyl nitrite, generation of precursors of Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate
5. Finally, the target product is obtained after deprotection and purification steps.
Safety Information:
-because Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate belongs to chemicals, safety measures should be paid attention to during operation, for example, wear appropriate chemical laboratory protective equipment (such as gloves, glasses, and lab clothes).
-The compound should be stored in a dry, cool place away from direct sunlight.
-in use and handling, to prevent inhalation, intake and contact with skin, eyes, so as not to cause irritation and damage.
-In case of accident or discomfort, seek medical attention and bring the safety data sheet of the compound for future reference.
Nature:
-Appearance: White or off-white solid
-Molecular formula: C31H29FN3O6P
-Molecular weight: 605.56g/mol
-Melting point: about 130-145 ° C
-Solubility: Slightly soluble in water, soluble in some organic solvents
Use:
- Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate is mainly used for peptide synthesis in the fields of biochemistry and organic synthesis, especially the study of peptide modification.
-It can be used as an intermediate in the design and synthesis of anti-cancer drugs, and has anti-tumor activity.
-It can also be used for protecting groups in polypeptide synthesis and solid phase synthesis.
Method:
The preparation of Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate usually adopts the method of organic synthesis, it can be synthesized in the laboratory by the following steps:
1. Preparation of (4-fluorophenyl) propionitrile
2. (4-fluorophenyl) propionitrile reacts with P-benzophenol to generate (4-(benzyloxy) phenyl) propionitrile
3. Reaction of (4-(benzyloxy) phenyl) propionitrile with (2R,3S)-1-benzylamino-2-oxo-3-azetidine yields (2R,3S)-1-(4-(Benzyloxy) phenyl)-2-oxo-4-cyano-3-azetidine
4. Reaction of (2R,3S)-1-(4-(benzyloxy) phenyl)-2-oxo-4-cyano-3-azetidine with methyl nitrite, generation of precursors of Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate
5. Finally, the target product is obtained after deprotection and purification steps.
Safety Information:
-because Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepanoate belongs to chemicals, safety measures should be paid attention to during operation, for example, wear appropriate chemical laboratory protective equipment (such as gloves, glasses, and lab clothes).
-The compound should be stored in a dry, cool place away from direct sunlight.
-in use and handling, to prevent inhalation, intake and contact with skin, eyes, so as not to cause irritation and damage.
-In case of accident or discomfort, seek medical attention and bring the safety data sheet of the compound for future reference.
Last Update：2024-04-09 21:04:16
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Product Name: Methyl (3R,4S)-1-(4-fluorophenyl)-2-oxo-4-[4-(phenylmethoxy)phenyl]-3-azetidinepropanoate Visit Supplier Webpage Request for quotation
CAS: 204589-80-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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CAS: 204589-80-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History
methyl 3-[(2S,3R)-2-[4-(benzyloxy)phenyl]-1-(4-fluorophenyl)-4-oxoazetidin-3-yl]propanoate
异丁酸叶醇酯
OIL OF NIOBE
三丁基-2-丙烯基氯化磷
77252-87-0
异丁酸叶醇酯
OIL OF NIOBE
三丁基-2-丙烯基氯化磷
77252-87-0